Silica reversed phase chromatography (RPC) is a popular purification tool for peptide-based therapeutics such as insulins and GLP-1 compounds. In many cases, high pH conditions are desirable in these chromatography process such as column regeneration by 0.1M NaOH solution, where conventional silica media suffers short lifetime. Hybrid silica particles are well known for high pH stability, but they are less than 10 µm in size and only used in analytical HPLC applications. There are no commercially available hybrid silica particles in 10 µm and larger sizes yet for process scale chromatography in the world, presumably due to low surface area of such hybrid particles, high manufacturing cost, and technical difficulties of their large scale production. Other hybrid coated silica particles have improved lifetime over silica particles at high pH, but still are not as stable as hybrid particles.

NanoMicro Technology is one of the few companies to commercialize monodispersed silica bulk media for separation and purification process. Our innovative Precisely Controlled Silica (PCS) technology allows us to manufacture monodispersed silica particles in large quantity and low cost (several hundred kilograms a batch with almost 100% yield). Based on the PCS technology, we have recently developed monodispersed hybrid silica - UniHybrid® Eterne particles in 10 µm size, which have very high surface area, good mechanical strength, and more than 10 times of chemical stability than silica particles, to meet the high demands of RPC media with high performance and high pH tolerance .

We offer products with various particle size and pore size. For detailed ordering information, please contact local sales or leave a message on this website.

Available after the end of November 2023