NMab Titan HC Protein A Affinity Chromatography Resin
NMab Titan HC is a next-generation high-performance Protein A affinity chromatography resin developed by NanoMicro. Featuring a high-rigidity matrix combined with optimized pore structure design, it is ideal for the separation and purification of monoclonal antibodies, bispecific antibodies, multispecific antibodies, and recombinant proteins containing Fc fragments. It delivers exceptional performance particularly in the purification of bispecific antibodies and high-molecular-weight antibody molecules. With four core advantages—high binding capacity, high rigidity, high mass transfer, and high alkali resistance—NMab Titan HC maintains excellent dynamic binding capacity even at high flow rates, meeting diverse needs from laboratory-scale preparation to pilot and industrial production. It empowers manufacturers to reduce costs and improve efficiency while ensuring product quality.
Performance Specifications
| Product Model | NMab Titan HC |
| Separation Principle | Protein A Affinity |
| Matrix | Agarose |
| Mean Particle Size | ~60 μm |
| Ligand Coupling Method | Epoxy Coupling |
| Dynamic Binding Capacity | ~80 mg·mL-1 (human IgG, 6 min residence time) |
| Max Operating Pressure | 0.5 MPa |
| CIP | 0.1-0.5 M NaOH |
| Recommended Flow Rate | 100-400 cm/h |
| pH Stability | 3-12 (working), 2-14 (CIP) |
| Chemical Stability | All commonly used buffers, 10 mM HCl, 0.1 M citric acid (pH 3), 6 M urea, 6 M guanidine HCl, 30% isopropanol, 20% ethanol. |
| Operating Temperature | 2-40 ℃ |
| Storage | 20% ethanol or 2% benzyl alcohol, 2-8 ℃ |
*Binding capacity determined at 10% antibody breakthrough
Ordering Information
| Product | Package Size | Catalog # |
| NMab Titan HC | 30 mL | 17080-060100-2030 |
| 50 mL | 17080-060100-2050 | |
| 100 mL | 17080-060100-2100 | |
| 300 mL | 17080-060100-2300 | |
| 500 mL | 17080-060100-2500 | |
| 1 L | 17080-060100-1001 | |
| 5 L | 17080-060100-1005 | |
| 10 L | 17080-060100-1010 | |
| 50 L | 17080-060100-1050 | |
| 100 L | 17080-060100-1100 |