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NMab Titan HC Protein A Affinity Chromatography Resin

NMab Titan HC is a next-generation high-performance Protein A affinity chromatography resin developed by NanoMicro. Featuring a high-rigidity matrix combined with optimized pore structure design, it is ideal for the separation and purification of monoclonal antibodies, bispecific antibodies, multispecific antibodies, and recombinant proteins containing Fc fragments. It delivers exceptional performance particularly in the purification of bispecific antibodies and high-molecular-weight antibody molecules. With four core advantages—high binding capacity, high rigidity, high mass transfer, and high alkali resistance—NMab Titan HC maintains excellent dynamic binding capacity even at high flow rates, meeting diverse needs from laboratory-scale preparation to pilot and industrial production. It empowers manufacturers to reduce costs and improve efficiency while ensuring product quality.

Performance Specifications

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Product ModelNMab Titan HC
Separation PrincipleProtein A Affinity
MatrixAgarose
Mean Particle Size~60 μm
Ligand Coupling MethodEpoxy Coupling
Dynamic Binding Capacity~80 mg·mL-1 (human IgG, 6 min residence time)
Max Operating Pressure0.5 MPa
CIP0.1-0.5 M NaOH
Recommended Flow Rate100-400 cm/h
pH Stability3-12 (working), 2-14 (CIP)
Chemical StabilityAll commonly used buffers, 10 mM HCl, 0.1 M citric acid (pH 3), 6 M urea, 6 M guanidine HCl, 30% isopropanol, 20% ethanol.
Operating Temperature2-40 ℃
Storage20% ethanol or 2% benzyl alcohol, 2-8 ℃


*Binding capacity determined at 10% antibody breakthrough


Ordering Information

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ProductPackage SizeCatalog #
NMab Titan HC30 mL17080-060100-2030
50 mL17080-060100-2050
100 mL17080-060100-2100
300 mL17080-060100-2300
500 mL17080-060100-2500
1 L17080-060100-1001
5 L17080-060100-1005
10 L17080-060100-1010
50 L17080-060100-1050
100 L17080-060100-1100


Note: Pre-packed columns are available in 7.7 mm × 22 mm, 16 mm × 25 mm, and 7.7 mm × 100 mm formats. For additional specifications or custom requirements, please contact us.