NanoQ-15L Ion Exchange Chromatography Resin

NanoMicro offers ion exchange chromatography resins based on polymer matrices (polyacrylate or polystyrene-divinylbenzene copolymers). The matrices undergo hydrophilic surface modification before coupling with ion exchange groups, providing excellent biocompatibility and physicochemical stability for biomacromolecules, significantly improving purification efficiency. Our Nano series IEX resins are designed for polishing of antibodies, proteins, peptides, nucleic acids, and small molecule drugs.

Fig. 1 SEM image of NanoQ-15L

Key features of NanoQ-15L:

Hydrophilic surface modification
High mechanical strength
High resolution
Low back pressure
Long service life
Excellent acid/alkali tolerance

Performance Specifications

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Name	NanoQ-15L
Separation Principle	Strong anion exchange
Matrix	Monodisperse polystyrene/divinylbenzene (PS-DVB)
Particle Size	~ 15μm
Ligand	—CH₂N⁺(CH₃)₃
Ligand Density	~0.27 meq/mL
Dynamic Binding Capacity	~55 mg/mL (Lys)
Maximum Pressure	6.0 MPa
CIP	0.5 M NaOH
Recommended Flow Rate	150-800 cm/h
pH Stability	Working pH: 2~12; CIP pH: 1-14
Chemical Stability	Compatible with all common buffers, 1 M acetic acid, 1 M sodium hydroxide, 1 M hydrochloric acid, 70% ethanol, 30% isopropanol, 30% acetonitrile, 1% SDS, 6 M guanidine hydrochloride, 8 M urea and other common organic solvents; avoid strong oxidizing agents. Do not expose to strong oxidants (e.g., hypochlorite), oxidizing acids (e.g., nitric acid), strong reducing agents (e.g., sulfite), acetone, or benzyl alcohol.
Operating Temperature	4~30 ℃
Storage Conditions	20% ethanol, 4~25 ℃

Notes:

1. pH stability range refers to the pH range for use, regeneration, and CIP
2. Dynamic binding capacity: lysozyme for cation exchangers, BSA for anion exchangers

Ordering Information

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Product	Package Size	Catalog #
NanoQ-15L	30 mL	04044-015100-2030
	50 mL	04044-015100-2050
	100 mL	04044-015100-2100
	300 mL	04044-015100-2300
	500 mL	04044-015100-2500
	1 L	04044-015100-1001
	5 L	04044-015100-1005
	10 L	04044-015100-1010
	50 L	04044-015100-1050
	100 L	04044-015100 -1100

Note: NanoMicro also offers preparative columns of 10 mm × 100 mm, 10 mm × 150 mm, and 10 mm × 250 mm. For 30 μm resins, pre-packed columns of 7.7 mm × 22 mm, 16 mm × 25 mm, and 7.7 mm × 100 mm are also available. For additional specifications or custom requirements, please contact us.