NanoQ-30L Ion Exchange Chromatography Resin

Ion exchange chromatography separates molecules based on differences in surface charge (type, quantity, and distribution), and is the most widely used method for the purification of biomacromolecules. NanoMicro's ion exchange chromatography resins are based on polymer matrices (polyacrylate or polystyrene-divinylbenzene copolymers) that undergo surface hydrophilic modification before being coupled with ion exchange groups, offering excellent biocompatibility and physicochemical stability for bioactive macromolecules, greatly improving purification efficiency. The Nano series ion exchange products from NanoMicro are designed for the polishing of antibodies, proteins, peptides, nucleic acids, and small molecule drugs.

Figure 1. SEM image of NanoQ-30L

Key features of NanoQ-30L:

Hydrophilic surface modification
High mechanical strength
High resolution
Low back pressure
Long service life
Excellent resistance to acid and alkali over extended periods

Performance Specifications

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Name	NanoQ-30L
Separation Principle	Strong anion exchange
Matrix	Monodisperse polystyrene/divinylbenzene (PS-DVB)
Particle Size	~ 30μm
Ligand	—CH₂N⁺(CH₃)₃
Ligand Density	~0.21 meq/mL
Dynamic Binding Capacity	~45 mg/mL (BSA)
Max Pressure	2.0 MPa
CIP	0.5 M NaOH
Recommended Flow Rate	250-1000 cm/h
pH Stability	Working pH: 2~12; CIP pH: 1-14
Chemical Stability	Compatible with all commonly used buffers, 1 M acetic acid, 1 M sodium hydroxide, 1 M hydrochloric acid, 70% ethanol, 30% isopropanol, 30% acetonitrile, 1% SDS, 6 M guanidine hydrochloride, 8 M urea, and other common organic solvents; avoid contact with strong oxidizing agents. Do not expose to strong oxidants (e.g., hypochlorite), oxidizing acids (e.g., nitric acid), strong reducing agents (e.g., sulfite), acetone, or benzyl alcohol.
Operating Temperature	4~30 ℃
Storage Conditions	20% ethanol, 4~25 ℃

Notes:

1. The pH stability range refers to the pH range for use, regeneration, and CIP.
2. Dynamic binding capacity: Lysozyme is used for cation exchangers, and bovine serum albumin (BSA) for anion exchangers.

Ordering Information

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Product	Package Size	Catalog #
NanoQ-30L	30 mL	04044-030100-2030
	50 mL	04044-030100-2050
	100 mL	04044-030100-2100
	300 mL	04044-030100-2300
	500 mL	04044-030100-2500
	1 L	04044-030100-1001
	5 L	04044-030100-1005
	10 L	04044-030100-1010
	50 L	04044-030100-1050
	100 L	04044-030100 -1100

Note: NanoMicro also offers preparative columns in 10 mm × 100 mm, 10 mm × 150 mm, and 10 mm × 250 mm dimensions. For the 30 μm resin, pre-packed columns are available in 7.7 mm × 22 mm, 16 mm × 25 mm, and 7.7 mm × 100 mm sizes. For additional specifications or custom requirements, please contact us.