NanoSP-15L Ion Exchange Chromatography Resin

NanoMicro provides ion exchange chromatography resins based on polymer matrices (polyacrylate or polystyrene-divinylbenzene copolymers). The matrices undergo hydrophilic surface modification before coupling with ion exchange groups, offering excellent biocompatibility and physicochemical stability for bioactive macromolecules, significantly improving purification efficiency. The Nano series ion exchange products from NanoMicro are suitable for polishing of antibodies, proteins, peptides, nucleic acids, and small molecule drugs.

Fig. 1. SEM image of NanoSP-15L

Key features of NanoSP-15L:

Hydrophilic surface modification
High mechanical strength
High resolution
Low back pressure
Long service life
Excellent acid/alkali tolerance

Performance Specifications

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Name	NanoSP-15L
Separation Principle	Strong cation exchange
Matrix	Monodisperse polystyrene/divinylbenzene (PS-DVB)
Particle Size	~ 15μm
Ligand	-(CH₂)₃SO₃^-
Ligand Density	~0.26 meq/mL
Dynamic Binding Capacity	~80 mg/mL (Lys)
Maximum Pressure	6.0 MPa
CIP	1 M NaOH
Recommended Flow Rate	150-800 cm/h
pH Stability	Working pH: 2~12; CIP pH: 1-14
Chemical Stability	Compatible with all common buffers, 1 M acetic acid, 1 M sodium hydroxide, 1 M hydrochloric acid, 70% ethanol, 30% isopropanol, 30% acetonitrile, 1% SDS, 6 M guanidine hydrochloride, 8 M urea and other common organic solvents. Avoid contact with strong oxidizing agents, oxidizing acids (e.g., nitric acid), strong reducing agents (e.g., sulfites), acetone, or benzyl alcohol.
Operating Temperature	4~30 ℃
Storage Conditions	20% ethanol, 4-25 ℃

Notes: 1. pH stability range refers to the pH range for use, regeneration, and CIP

2. Dynamic binding capacity: lysozyme for cation exchange, bovine serum albumin (BSA) for anion exchange

Ordering Information

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Product	Package Size	Catalog #
NanoSP-15L	30 mL	04042-015100-2030
	50 mL	04042-015100-2050
	100 mL	04042-015100-2100
	300 mL	04042-015100-2300
	500 mL	04042-015100-2500
	1 L	04042-015100-1001
	5 L	04042-015100-1005
	10 L	04042-015100-1010
	50 L	04042-015100-1050
	100 L	04042-015100 -1100

Note: NanoMicro also offers preparative columns of 10 mm × 100 mm, 10 mm × 150 mm, and 10 mm × 250 mm. For the 30 μm resin, pre-packed columns of 7.7 mm × 22 mm, 16 mm × 25 mm, and 7.7 mm × 100 mm are also available. For additional specifications or custom requirements, please contact us.