UniCM-50XS Weak Cation Exchange Chromatography Resin
NanoMicro UniCM-50XS weak cation exchange chromatography resin is based on a polymer matrix that has been surface-modified with hydrophilic groups and then coupled with ion exchange ligands. It offers excellent biocompatibility and physicochemical stability for bioactive molecules, significantly improving purification efficiency. It is ideally suited for the purification of small biomolecules such as small proteins, peptides, nucleic acids, and antibiotics.
UniCM-50XS features a hydrophilic surface modification that provides low non-specific binding, high resolution for small molecules, and high binding capacity. Key technical parameters are listed below:
Performance Specifications
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| Product Model | UniCM-50XS |
| Separation Principle | Weak cation exchange |
| Matrix | Polymethacrylate (PMMA) |
| Particle Size | 55 μm |
| Ligand | —CH2COO- |
| Ligand Density | ~0.23 meq·mL-1 |
| Dynamic Binding Capacity | ~55 mg·mL-1 (Lysozyme) |
| Maximum Pressure | 0.8 MPa |
| CIP | 0.5 M NaOH |
| Recommended Flow Rate | 100-500 cm/h |
| pH Stability | 2~12 |
| Chemical Stability | Compatible with all common buffers, 1 M acetic acid, 1 M NaOH, 1 M HCl, 70% ethanol, 30% isopropanol, 30% acetonitrile, 1% SDS, 6 M guanidine-HCl, 8 M urea, and other common organic solvents; avoid strong oxidizing agents. |
| Operating Temperature | 4-30 ℃ |
| Storage Conditions | 20% ethanol, 4-25℃ |
Ordering Information
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| Product | Package Size | Catalog # |
| UniCM-50XS | 30 mL | 04021-050030-2030 |
| 50 mL | 04021-050030-2050 | |
| 100 mL | 04021-050030-2100 | |
| 300 mL | 04021-050030-2300 | |
| 500 mL | 04021-050030-2500 | |
| 1 L | 04021-050030-1001 | |
| 5 L | 04021-050030-1005 | |
| 10 L | 04021-050030-1010 | |
| 50 L | 04021-050030-1050 | |
| 100 L | 04021-050030-1100 |
Note: NanoMicro offers a wide range of preparative pre-packed columns, including 7.7*22mm (NmTRAP 1mL), 16*25mm (NmTRAP 5mL), 7.7*100mm (NmSCREEN 4.7mL), 16*100mm (NmPREP 20mL), 26*100mm (NmPREP 50mL), as well as NmVALID and NmLOAD series preparative pre-packed columns with adjustable bed heights (inner diameters of 8/11/16/26/50mm), and NmPILOT se