UniPS 15-300 Reversed-phase Polymer Chromatography Resin

NanoMicro offers monodisperse reversed-phase polymer chromatography resins in various particle sizes and pore sizes. Based on matrix and characteristics, they are available in five series: UniPS^®, Uni^®PMM, Uni^®PSN, Uni^®PSA, and NM. These resins are primarily used for laboratory analysis and purification of organic compounds, natural products, proteins, insulin, peptides, and nucleic acids. With excellent alkaline resistance, long service life, and the ability to prevent tailing of basic compounds, they complement reversed-phase silica resins in separation performance and solvent compatibility.

Figure 1. Chemical structure of UniPS®

UniPS^® 15-300 monodisperse reversed-phase polymer resin is based on highly cross-linked polystyrene/divinylbenzene (PS/DVB) (Figure 1). The abundant phenyl groups in the matrix render it highly hydrophobic with strong reversed-phase retention, and enable unique surface modifications for diverse selectivity. The high cross-linking density provides high mechanical strength and chemical stability, allowing operation under high pressure, repeated DAC packing, and resistance to extreme acidic or alkaline pH and mixed organic solvents during regeneration.

Compared to similar products on the market, UniPS® 15-300 offers the following advantages:

• Narrower particle size distribution: CV ≤ 3%;

• High mechanical strength: highly cross-linked PS/DVB matrix for high pressure resistance; withstands repeated high-pressure DAC packing without breakage;

• Long service life: corrosion-resistant, contamination-resistant, easy to regenerate, and cost-effective;

• Excellent chemical stability: suitable for purification across pH 1-14.