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UniHybrid 10-120 C8 Hybrid Silica Chromatography Resin

The UniHybrid® series resins are manufactured from high-purity monodisperse porous silica microspheres produced using NanoMicro's proprietary technology. A dense surface hybridization is applied to the particle surface and pore structure, introducing an organic-inorganic hybrid layer containing methylene bridge structures, followed by bonding and end-capping. This unique surface hybridization technology significantly enhances the chemical stability of the resin, providing acid and alkaline pH tolerance similar to polymer-based resins. As a result, it combines the mechanical strength of high-purity silica resins with the chemical stability of polymer resins, along with the excellent chromatographic purification performance derived from both. Additionally, the surface chemistry modification alters the silanol density and increases the organic carbon content, imparting unique separation selectivity to the hybrid silica.

Compared to similar products on the market, UniHybrid® 10-120 C8 offers the following unique advantages:

  • Monodisperse silica resin with extremely narrow particle size distribution, CV ≤ 5%;

  • Precisely controlled pore size and distribution, effective specific surface area, and pore volume, enabling high loading capacity;

  • Uniform particle size, surface modification, and pore design deliver high column efficiency and superior separation and purification performance;

  • Excellent chemical stability, suitable for purification across pH 1-11.

Performance Specifications

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Separation Principle

Reversed Phase Chromatography

Matrix

Monodisperse Silica

Particle Size

10 µm

Pore Size

120 Å

Particle Size CV

≤5%

Pressure Limit

<600 bar

Pore Volume

~1.00 cm3/g

Specific Surface Area

~310 m2/g

Bulk density

~0.57 g/mL

Carbon Content

≥10%

pH Range

1~11


Ordering Information

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Product 

Package Size

Catalog #

UniHybrid® 10-120 C8

30 g, 50 g, 100 g, 100 g, 500 g, 1 kg, 5 kg, 10 kg, 50 kg, 100 kg

19502-100012


Note: NanoMicro also offers preparative columns with inner diameters of 10/21.2/30/50 mm and lengths of 100/150/250 mm. For additional specifications or custom configurations, please contact us.