UniHybrid 10-300 C18 Hybrid Silica Chromatography Resin

The UniHybrid® series chromatography resins are based on high-purity monodisperse porous silica microspheres produced by NanoMicro's patented technology. A dense surface hybridization is applied to the particle and pore structure surfaces, introducing an organic-inorganic hybrid layer containing methylene bridge structures on the silica surface, followed by bonding and end-capping. This unique surface hybridization technology significantly enhances the chemical stability of the resin, providing acid and alkaline pH tolerance similar to polymer-based resins. As a result, it combines the mechanical strength of high-purity silica resins with the chemical stability of polymer resins, along with the excellent separation performance derived from both in chromatographic purification. Additionally, the surface chemical treatment alters the silanol density and increases the organic carbon content, imparting unique separation selectivity to the hybrid silica.

Compared to similar products on the market, UniHybrid® 10-300 C18 offers the following unique advantages:

• Monodisperse silica resin with extremely narrow particle size distribution, CV ≤ 5%;

• Precisely controlled pore size and distribution, effective specific surface area, and pore volume, enabling high loading capacity;

• Uniform particle size, surface modification, and pore design deliver high column efficiency and excellent separation performance in chromatography;

• Excellent chemical stability, suitable for separation and purification at pH 1-11.