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UniSil 10-120 C18 Aq Reversed-Phase Silica Chromatography Resin

UniSil® 10-120 C18 Aq is a key member of the NanoMicro UniSil®  product line. This reversed-phase chromatography resin features a surface-modified UniSil®  silica matrix with bonded reversed-phase groups (Figure 1), offering uniform particle size, high mechanical strength, high column efficiency, and high resolution. Its pore structure and chemical bonding are particularly well-suited for the separation and purification of small molecules such as antibiotics, peptides, and natural products.

UniSil® 10-120 C18 Aq employs advanced surface bonding and end-capping technology, providing excellent chemical stability. After 5 years of storage at room temperature, re-testing of multiple batches shows no significant changes in QC results compared to initial analysis.

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Chemical Structure of UniSil® 10-120 C18 Aq


Compared to similar products on the market, UniSil® 10-120 C18 Aq offers the following unique advantages:

  • Monodisperse silica resin with extremely narrow particle size distribution, CV ≤ 5%;

  • Precisely controlled pore size and distribution, effective specific surface area, and pore volume for high loading capacity;

  • Unique end-capping technology effectively modulates residual silanol groups on the silica surface to meet diverse application needs;

  • Excellent chemical stability, suitable for separation and purification at pH 2-8.

Performance Specifications

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Separation PrincipleReversed-Phase Chromatography
MatrixMonodisperse Silica
Particle Size10 µm
Pore Size120 Å
Particle Size CV≤5%
Pressure Tolerance<600 bar
Pore Volume~1.00 cm3/g
Specific Surface Area~350 m2/g
Bulk density~0.60 g/mL
Carbon Content≥15%
pH Range2~8


Ordering Information

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Product NamePackaging SizeStock Code
UniSil® 10-120 C18 Aq30 g19006-100012-4030
50 g19006-100012-4050
100 g19006-100012-4100
300 g19006-100012-4300
500 g19006-100012-4500
1 kg19006-100012-3001
5 kg19006-100012-3005
10 kg19006-100012-3010
50 kg19006-100012-3050
100 kg19006-100012-3100


Note: NanoMicro also offers preparative columns with inner diameters of 10/21.2/30/50 mm and lengths of 100/150/250 mm. For additional specifications or custom configurations, please contact us.