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UniSil 10-120 C8 Reversed-Phase Silica Chromatography Resin

UniSil® 10-120 C8 is a key member of the NanoMicro UniSil® product line. This reversed-phase chromatography resin is prepared by surface modification of the UniSil® silica matrix to configure reversed-phase bonded groups (Figure 1). It features uniform particle size, high mechanical strength, high column efficiency, and high resolution. Its pore structure and chemical bonding are particularly well-suited for the separation and purification of small molecules such as antibiotics, peptides, and natural products.

UniSil® 10-120 C8 employs advanced surface bonding and end-capping technology, providing excellent chemical stability. After 5 years of storage at room temperature, multiple batches of the resin were retested, and the quality control test results showed no significant changes compared to the initial quality control analysis.

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Chemical Structure of UniSil® 10-120 C8


Compared to similar products on the market, UniSil® 10-120 C8 offers the following unique advantages:

  • Monodisperse silica resin with an extremely narrow particle size distribution, CV ≤ 5%;

  • Precisely controlled pore size and distribution, effective specific surface area, and pore volume, resulting in high loading capacity;

  • Unique end-capping technology effectively modulates residual silanol groups on the silica surface to meet diverse application requirements;

  • Excellent chemical stability, suitable for separation and purification at pH 2-8.

Performance Specifications

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Separation PrincipleReversed-Phase Chromatography
MatrixMonodisperse Silica
Particle Size10 µm
Pore Size120 Å
Particle Size CV≤5%
Pressure Tolerance<600 bar
Pore Volume~1.00 cm3/g
Specific Surface Area~350 m2/g
Bulk density~0.50 g /mL
Carbon Content~10%
pH Range2~8


Ordering Information

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Product Package SizeCatalog #
UniSil® 10-120 C830 g19002-100012-4030
50 g19002-100012-4050
100 g19002-100012-4100
300 g19002-100012-4300
500 g19002-100012-4500
1 kg19002-100012-3001
5 kg19002-100012-3005
10 kg19002-100012-3010
50 kg19002-100012-3050
100 kg19002-100012-3100


Note: NanoMicro also offers preparative columns with inner diameters of 10/21.2/30/50 mm and lengths of 100/150/250 mm. For more specifications or custom options, please contact us.