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UniSil 20-120 FG C18 Reversed Phase Silica Chromatography Resin

UniSil® 20-120 FG C18 is a key member of NanoMicro's UniSil®  product line. This reversed-phase chromatography resin features a surface-modified UniSil®  silica matrix with bonded reversed-phase groups (Figure 2), offering uniform particle size, high mechanical strength, high column efficiency, and high resolution. Its pore structure and chemical bonding are particularly well-suited for the separation and purification of small molecules such as antibiotics, peptides, and natural products.

UniSil® 20-120 FG C18 employs advanced surface bonding and end-capping technology, providing excellent chemical stability. After 5 years of storage at room temperature, multiple batches of the resin were retested, and the quality control results showed no significant changes compared to the initial QC analysis.

Chemical Structure of UniSil® 20-120 FG C18


Compared to similar products on the market, UniSil® 20-120 FG C18 offers the following unique advantages:

  • Monodisperse silica resin with an extremely narrow particle size distribution, CV ≤ 5%;

  • Precisely controlled pore size and distribution, effective specific surface area, and pore volume, resulting in high loading capacity;

  • Unique end-capping technology effectively modulates residual silanol groups on the silica surface to meet diverse application needs;

  • Excellent chemical stability, suitable for separation and purification at pH 2-8.

Performance Specifications

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Separation PrincipleReversed-phase chromatography
MatrixMonodisperse silica
Particle Size20 µm
Pore Size120 Å
Particle Size CV≤5%
Pressure Limit<600 bar
Pore Volume~1.00 cm3/g
Specific Surface Area~350 m2/g
Bulk density~0.55 g /mL
Carbon Content~15%
pH Range2~8


Ordering Information

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Product NamePackaging SizeStock Code
UniSil® 20-120 FG C1830 g19203-200012-4030
50 g19203-200012-4050
100 g19203-200012-4100
300 g19203-200012-4300
500 g19203-200012-4500
1 kg19203-200012-3001
5 kg19203-200012-3005
10 kg19203-200012-3010
50 kg19203-200012-3050
100 kg19203-200012-3100


Note: NanoMicro also offers preparative columns with inner diameters of 10/21.2/30/50 mm and lengths of 100/150/250 mm. For additional specifications or custom configurations, please contact us.