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UniSil 8-120 C18 Ultra Reversed Phase Silica Chromatography Resin

UniSil® 8-120 C18 Ultra is a key member of NanoMicro's UniSil® product line. This reversed-phase chromatography resin is prepared by surface modification of the UniSil® silica matrix to configure reversed-phase bonded groups, offering uniform particle size, high mechanical strength, high column efficiency, and high resolution. Its pore structure and chemical bonding are particularly well-suited for the separation and purification of small molecules such as antibiotics, peptides, and natural products.

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Figure 1. Chemical structure of UniSil® 8-120 C18 Ultra

UniSil® 8-120 C18 Ultra employs advanced surface bonding and end-capping technology, providing excellent chemical stability. After 5 years of storage at room temperature, multiple batches of the resin were re-tested, and the quality control results showed no significant changes compared to the initial QC analysis.

Compared to similar products on the market, UniSil® 8-120 C18 Ultra offers the following unique advantages:

• Monodisperse silica resin with extremely narrow particle size distribution, CV ≤ 5%;

• Precisely controlled pore size and distribution, effective specific surface area, and pore volume for high loading capacity;

• Unique end-capping technology effectively modulates residual silanol groups on the silica surface to meet diverse application needs;

• Excellent chemical stability, suitable for separation and purification at pH 2-10.


Performance Specifications

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Separation PrincipleReversed-phase chromatography
MatrixMonodisperse silica
Particle Size8 µm
Pore Size120 Å
Particle Size CV≤5%
Pressure Tolerance<600 bar
Pore Volume~1.0 cm3/g
Specific Surface Area~300 m2/g
Bulk density~0.55 g /mL
Carbon Content≥15%
pH Range2~10


Ordering Information

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Product 

Package Size

Catalog #
UniSil® 8-120 C18 UltraStandard packaging available in 30g, 50g, 100g, 300g, 500g, 1kg, 5kg, 10kg, 50kg, 100kg19101-080012


Note: NanoMicro also offers preparative columns with inner diameters of 10/21.2/30/50 mm and lengths of 100/150/250 mm. For additional specifications or custom configurations, please contact us.