UniSil Revo 10-100 C18 Reversed Phase Silica Chromatography Resin

UniSil^® Revo 10-100 C18 is a key member of NanoMicro's UniSil^® Revo product line. Featuring revolutionary micropore control technology that creates interconnected pores with thicker pore walls, this resin offers superior mechanical strength, selectivity, and pH tolerance. This reversed-phase chromatography resin is prepared by surface modification of the UniSil^® Revo silica matrix to introduce reversed-phase bonded groups (Figure 1). Its pore structure and chemical bonding are particularly well-suited for the separation and purification of small molecules such as GLP-1, insulin, peptides, and oligonucleotides.

Figure 1. Chemical structure of UniSil^® Revo 10-100 C18

UniSil^® Revo 10-100 C18 utilizes advanced surface bonding and end-capping technology, providing excellent chemical stability.

Compared to similar products on the market, UniSil^® Revo 10-100 C18 offers the following unique advantages:

• Monodisperse silica resin with extremely narrow particle size distribution, CV ≤ 5%;

• Precisely controlled pore size, pore size distribution, effective surface area, and pore volume, delivering high loading capacity and high resolution;

• UniSil^® Revo 10-100 offers three key advantages over other silica resins:

   ■ Similar pore size and retention time to Kromasil 100-10, serving as a direct replacement for Kromasil 100-10.

   ■ Surface passivated for over 3-fold improved chemical stability under high pH conditions.

   ■ Further optimized C18/C8/C4 bonded phases to improve insulin and GLP-1 yield and purity.