Upgraded Launch! NMab Titan HC High-Capacity Protein A Resin Redefines Purification Efficiency
Antibody drugs have become the core of biopharmaceuticals due to their precise targeting, covering mAbs, bispecific or multispecific antibodies, ADCs, and more. However, their complex structural forms and diverse impurity profiles pose significant challenges to purification processes.
Conventional Protein A resins face binding capacity limitations and process stability challenges, directly impacting product quality, production costs, and scale-up efficiency.
Key Highlights
NanoMicro introduces the NMab Titan HC high-performance Protein A resin, redefining antibody purification withfour core advantages:
High Capacity
Significantly enhanced dynamic binding capacity, with a particularly pronounced advantage for complex antibody molecules such as bispecific antibodies with larger molecular weights
High Mass Transfer
Molecular diffusion efficiency is greatly improved, reaching binding equilibrium within 4 minutes to boost production efficiency
High Rigidity
Structurally stable and durable, with a bed that resists collapse to ensure production stability
High Caustic Resistance
Excellent caustic resistance extends resin service life and reduces replacement costs
NMab Titan HC precisely addresses the technical pain points of antibody purification, helping enterprises reduce costs and increase efficiency while ensuring product quality, and efficiently completing process scale-up.
Product Technical Specifications
01
High Capacity
Determines Resin Purification Efficiency
Dynamic binding capacity (DBC) directly impacts the processing capability of the resin. A high DBC value means that efficient purification can be achieved with a smaller column volume, thereby reducing equipment investment and resin costs. For example, with different mAb and bsAb feedstreams, NMab Titan HC demonstrates higher dynamic binding capacity under the same conditions (compared to a certain international brand *A), enabling reduced resin usage during scale-up and optimized production costs.
Figure 1: Comparison of binding capacity for different mAb/bsAb
02
High Rigidity
Stable Assurance for High-Flow-Rate Production
The mechanical strength and pressure resistance of the resin are key to ensuring production efficiency. Excellent mechanical properties not only support high-flow-rate operations, significantly improving production efficiency, but also reduce the risk of reduced column efficiency and product loss caused by resin breakage. (Tested in a 1200mm column, bed height 209mm, compression ratio: 1.15, test solution: pure water)
Figure 2: Pressure-flow rate curve for 1.2-meter column (H:209mm)
03
High Caustic Resistance
Extends Resin Service Life
Protein A resins require regular caustic cleaning to remove impurities and microorganisms, so caustic resistance directly affects their service life. In accelerated caustic resistance tests at different concentrations (0.1M/0.3M/0.5M) NaOH, the resin retained more than 80% of its initial binding capacity after 72 hours of soaking.
Figure 3: Caustic resistance test curves at different concentrations
04
High Mass Transfer
Improves Production Efficiency
As shown in the figure below, saturation is essentially reached at a 4-minute residence time, demonstrating excellent mass transfer performance, which is conducive to improving production efficiency and reducing production costs.
Figure 4: DBC curves at different residence times (mAb)
05
Purification Profile Comparison
Comparison of Purification Data for a Bispecific Antibody Feedstream
Compared to a certain international brand *A, the performance data are comparable:
Purification profile of a certain international brand *A
Figure 5
NMab Titan HC purification profile
Figure 6
The purification test data are as follows:
During antibody process scale-up, the dynamic binding capacity, mechanical performance, quality comparability, caustic resistance, and service life of Protein A resins are core considerations that help enterprises optimize production costs and enhance market competitiveness.
In addition, the supplier's supply stability, regulatory compliance, and technical support capabilities are equally important to ensure a long-term, stable supply chain.
Choose NMab Titan HC (Cat. No.: 17080-060100) for more efficient and economical process scale-up!
Contact us today to obtain detailed technical documentation, application case studies, or to arrange small-scale sample testing for NMab Titan HC. Let us work together to safeguard the stable production of biologics.
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Upgraded Launch! NMab Titan HC High-Capacity Protein A Resin Redefines Purification Efficiency
