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UniHybrid 8-120 C8 Hybrid Silica Chromatography Resin

The UniHybrid® series is manufactured from high-purity, monodisperse, porous silica microspheres produced using NanoMicro's proprietary technology. A dense surface hybridization is applied to the particle surface and pore structure, introducing an organic-inorganic hybrid layer containing methylene bridge structures onto the silica surface, followed by bonding and end-capping. This unique surface hybridization technology significantly enhances the chemical stability of the resin, providing acid and base pH tolerance comparable to polymer-based resins. As a result, it combines the mechanical strength of high-purity silica resins with the chemical stability of polymer resins, along with the superior performance derived from both in chromatographic purification. Additionally, the surface chemistry modification alters the silanol density and increases the carbon content, imparting unique separation selectivity to the hybrid silica.

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Compared to similar products on the market, UniHybrid® 8-120 C8 offers the following unique advantages:

  • Monodisperse silica resin with an extremely narrow particle size distribution, CV ≤ 5%;

  • Precisely controlled pore size and distribution, effective surface area, and pore volume for high loading capacity;

  • Uniform particle size, surface modification, and pore design deliver high column efficiency and excellent separation and purification performance;

  • Excellent chemical stability, suitable for purification across pH 1-11.

Performance Specifications

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Separation PrincipleReversed Phase Chromatography
MatrixMonodisperse Silica
Particle Size8 µm
Pore Size120 Å
Particle Size CV≤5%
Pressure Limit<600 bar
Pore Volume~1.00cm3/g
Specific Surface Area~310 m2/g
Bulk density~0.60 g /mL
Carbon Content~13%
pH Range1~11


Ordering Information

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Product Package SizeCatalog #
UniHybrid® 8-120 C830 g19502-080012-4030
50 g19502-080012-4050
100 g19502-080012-4100
300 g19502-080012-4300
500 g19502-080012-4500
1 kg19502-080012-3001
5 kg19502-080012-3005
10 kg19502-080012-3010
50 kg19502-080012-3050
100 kg19502-080012-3100


Note: NanoMicro also offers preparative columns with inner diameters of 10/21.2/30/50 mm and lengths of 100/150/250 mm. For additional specifications or custom configurations, please contact us.