NMPeptide 2-CTC Solid-Phase Peptide Synthesis Resin

Product Description

2-CTC resin is commonly used for Fmoc-based peptide synthesis. The 2-CTC linker is acid-labile and moisture-sensitive. Its advantage lies in the fact that loading the first amino acid does not require pre-activation, which can avoid side reactions such as racemization.

After synthesis, cleavage can be performed using AcOH/TFE/DCM or low-concentration TFA to obtain fully side-chain-protected peptide fragments. This resin is particularly suitable for the synthesis of peptides containing C-terminal cysteine, histidine, methionine, tyrosine, and proline residues.

The NMPeptide series of solid-phase peptide synthesis resins offers the following advantages:

• High synthesis efficiency: The resin has a uniform particle size distribution and uniform functional group distribution, providing good reactivity that accelerates the coupling of amino acids to the growing peptide chain, thereby improving synthesis efficiency.

• Good chemical stability: It swells well in non-polar solvents. During synthesis, the resin maintains chemical stability, reducing impurity generation.

• High mechanical strength: It withstands various physical and chemical stresses during synthesis, maintaining resin integrity.

Figure 1. Schematic diagram of NMPeptide 2-CTC structure